Schedule I Controlled Substances Research Information

Summary

It is DEA’s goal to maintain a positive working relationship with all of its registrants, including researchers. DEA and researchers have a common interest in the appropriate use of controlled substances. An effective working relationship to ensure compliance with federal requirements will continue to produce lasting benefits on a national scale.

“There is a legitimate need for conducting research with controlled substances. However, the diversion and abuse of pharmaceutical controlled substances remains a public health concern in the United States. Your role in the proper use of controlled substances in your research helps protect society against drug abuse and diversion. Your compliance with the CSA and its objectives is a powerful resource for protecting the public health, assuring patient safety, and preventing the diversion of controlled substances.”
- Kristi N. O’Malley, former Assistant Administrator Diversion Control Division, DEA

Researcher’s Manual (Revised 2022)

Before You Apply: Checklist of Required Materials
Controlled Substance Code Number

Registration

To apply for a new registration (DEA Form 225), renew an existing registration (DEA Form 225a), make changes to an existing registration (e.g., update name or address, add or amend a protocol, add drug codes, change drug quantities, etc.), or check on the status of your registration application, please see the links found at Registration (usdoj.gov).

Other relevant DEA Forms include:

Official Order Forms
As of October 30, 2021, the Drug Enforcement Administration is implementing the mandatory use of a single sheet DEA 222 Order Form and the triplicate DEA Order Forms will no longer be available or utilized as stated in the Code of Federal Regulations §1305.20(a). If you are needing to relinquish unused triplicate DEA Order Forms, please send them to DEA Registration Section, 8701 Morrissette Drive, Springfield, Virginia 22152.

Large Volume Order Forms (DEA Form 222)

 

Registration Resources

Registrant Population (Active)

 

Registration Support

Contact scientific staff for help with your schedule I controlled substances research application. 1-800-882-9539 (8:30 am-5:50 pm ET).

Email: DPEScheduleIResearch@dea.gov - Be sure to include your DEA Registration number in your email.

or Diversion Investigator

 

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